I have Weber Black Tolex 5E3x2 (4 6v6s) almost looks like a Blues Jr and I play it with a Fender FR1000 reverb unit. (Extremely underrated reverb, if you don't play surf music, I highly recommend one, the reverb beats any spring reverb pedal that I've used.
5e3x2 Great tones, very classic old school in a 1940s-1950s kind of way when dialed low. You can play 40s Jazz, Jump Blues, 50s Pop/Rock, any Blues... Past 3 on the dial, it turns to mean, and I mean Ken Fisher Trainwreck mean!
If an amp is of quality and set up right (right tubes, right speaker, etc) Shouldn't be that much of a call for pedals other than in some cases a buffer or compressor/sustainer.
5E3 is one great circuit. All great Tweeds have a dirty but clean dynamic.