Anyone using HX FX? Or maybe a Helix user?

I use Helix Native regularly, so I am familiar with the Helix platform, however that doesn't need the 4CM, so I'll give it my best shot. I believe you stumbled on the fix for all of it, making sure a loop is inserted; there may be a "loop on/off" option somewhere in each preset that needs to be switched, or maybe a global setting? The fact that it works fine, then it doesn't later on, is a clue that it may be a setting. Do you find that it works, then you change a preset, then go back and it doesn't work anymore?

I had the exact same experience last week. I have a Helix Rack that I've owned for almost 2 years. A few weeks ago I bought a used Kemper and wanted to run 4cm into the Helix. I followed all the diagrams but had no sound coming from the Helix. After monkeying around with it, it finally worked but I swear I had it set up properly to begin with(I obviously didn't). Since then it's been 100% reliable even though I'm not exactly sure what fixed it.

I don't have the HXFX but the concept should be the same as a regular Helix. You do need to have an fx loop block for each preset you're using. Otherwise the signal coming back to the HX doesn't get added to your chain. I use separate Send 1 and Return 1 blocks rather than a single FX Loop 1 so I can put stuff between the amp and cab but you should be able to get away just with the single fx loop 1 to save space.

There's lots of talk about making the fx loop always on in the global settings so you don't have to add a loop to every patch. We'll see if Line 6 decides to implement that in the future.

Yeah, all my amps dont have effects loops so I've never had a reason to try the 4cm until now. With no loop, you just have to run the HXfx infront of the amp which is what I'd do with a normal pedal board.

Funny you mention the 4cm preset. I tried using that and I think that's what screwed me up. Not sure why, but once I moved to a blank preset and added the send/returns, that's when things started moving in the right direction.

Thanks mojo!  I checked when it arrived and it had the latest update.  I believe it's 2.82.

It's strange, I've had no more issues since the last time I had a problem, which was a few days ago.  I downloaded some worship presets and some of them are great!  Fantastic might be a better word.  I'm playing some slide tomorrow and it sounds better than anything I was getting out of the ME-70.
Tomorrow I'll be plugging into a different amp at church, but it's the same brand (Fuchs), just less wattage.  So I don't expect to have any issues other than some minor adjustments on the amp.

Thanks!  I've downloaded all the free patches last week, and I purchased some also, but I think the ones I purchased were from somewhere else...?  Not sure, I mean, it was last week!  

Thanks, I will check out Alex and Jason! The way the patches are laid out, that's something I was really struggling with before purchasing the presets. I'm still not sure if I like snapshot mode or stomp mode better.

HX FX sounded great at church today, I'll stick my neck out and say it's the best I've ever sounded at church. The delays and reverbs are great and gave me a much fuller tone, but still clear enough to hear all the notes. I used an Elevation patch that I purchased, and 3 different Snapshots that came with it.

I've had no more issues with the original problem I mentioned above, so it must have been something I did, although I have no idea what!

Lord that looks complicated Bill...multi level menus freak me out...analog man in a digital world.